Leukemia cutis is clinically divided into a specific and non-specific type. The former shows a malignant cell infiltration on histologic examination.
A 42-year-old man presented with erythematous macules, plaques, and nodules on the trunk, face, and both upper extremities. The skin lesions had gradually spread from the erythematous macules and nodules on the shoulder area over seven months. He
also
had axillary and inguinal lymph node enlargement. Bone marrow biopsy and peripheral blood smear specimen showed changes of acute lymphocytic leukemia. A skin biopsy specimen showed diffuse dermal infiltration of atypical lymphocytes. In
immunohistochemical staining these cells were positive for mainly leukocyte common antigen and Leu 3.
We treated him with various combined chemotherapy, and his skin lesion were improved.
(Kor J Dermatol 1996;34 (3):445~449)
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